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Primate-specific isoform of Nedd4-1 regulates substrate binding via Ser/Thr phosphorylation and 14-3-3 binding

Nedd4 (Nedd4-1) is an E3 ubiquitin ligase involved in crucial biological processes such as growth factor receptor signaling. While canonical Nedd4-1 comprises a C2-WW((4))-HECT domain architecture, alternative splicing produces non-canonical isoforms that are poorly characterized. Here we characteri...

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Detalles Bibliográficos
Autores principales:	Kefalas, George, Rotin, Daniela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589272/ https://www.ncbi.nlm.nih.gov/pubmed/37863970 http://dx.doi.org/10.1038/s41598-023-44761-9

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