Nanomechanical action opens endo-lysosomal compartments

Endo-lysosomal escape is a highly inefficient process, which is a bottleneck for intracellular delivery of biologics, including proteins and nucleic acids. Herein, we demonstrate the design of a lipid-based nanoscale molecular machine, which achieves efficient cytosolic transport of biologics by des...

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Detalles Bibliográficos
Autores principales: Zhao, Yu, Ye, Zhongfeng, Song, Donghui, Wich, Douglas, Gao, Shuliang, Khirallah, Jennifer, Xu, Qiaobing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589329/
https://www.ncbi.nlm.nih.gov/pubmed/37863882
http://dx.doi.org/10.1038/s41467-023-42280-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589329/
https://www.ncbi.nlm.nih.gov/pubmed/37863882
http://dx.doi.org/10.1038/s41467-023-42280-9

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