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Prediction of CRISPR-Cas9 off-target activities with mismatches and indels based on hybrid neural network
The CRISPR/Cas9 system has significantly advanced the field of gene editing, yet its clinical application is constrained by the considerable challenge of off-target effects. Although numerous deep learning models for off-target prediction have been proposed, most struggle to effectively extract the...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Research Network of Computational and Structural Biotechnology
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589368/ https://www.ncbi.nlm.nih.gov/pubmed/37867973 http://dx.doi.org/10.1016/j.csbj.2023.10.018 |