Prediction of CRISPR-Cas9 off-target activities with mismatches and indels based on hybrid neural network

The CRISPR/Cas9 system has significantly advanced the field of gene editing, yet its clinical application is constrained by the considerable challenge of off-target effects. Although numerous deep learning models for off-target prediction have been proposed, most struggle to effectively extract the...

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Detalles Bibliográficos
Autores principales: Yang, Yanpeng, Li, Jian, Zou, Quan, Ruan, Yaoping, Feng, Hailin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589368/
https://www.ncbi.nlm.nih.gov/pubmed/37867973
http://dx.doi.org/10.1016/j.csbj.2023.10.018

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