In silico discovery of repetitive elements as key sequence determinants of 3D genome folding

Natural and experimental genetic variants can modify DNA loops and insulating boundaries to tune transcription, but it is unknown how sequence perturbations affect chromatin organization genome wide. We developed a deep-learning strategy to quantify the effect of any insertion, deletion, or substitu...

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Detalles Bibliográficos
Autores principales: Gunsalus, Laura M., Keiser, Michael J., Pollard, Katherine S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589630/
https://www.ncbi.nlm.nih.gov/pubmed/37868032
http://dx.doi.org/10.1016/j.xgen.2023.100410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589630/
https://www.ncbi.nlm.nih.gov/pubmed/37868032
http://dx.doi.org/10.1016/j.xgen.2023.100410

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