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In silico discovery of repetitive elements as key sequence determinants of 3D genome folding
Natural and experimental genetic variants can modify DNA loops and insulating boundaries to tune transcription, but it is unknown how sequence perturbations affect chromatin organization genome wide. We developed a deep-learning strategy to quantify the effect of any insertion, deletion, or substitu...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589630/ https://www.ncbi.nlm.nih.gov/pubmed/37868032 http://dx.doi.org/10.1016/j.xgen.2023.100410 |