Human Presenilin-1 delivered by AAV9 rescues impaired γ-secretase activity, memory deficits, and neurodegeneration in Psen mutant mice

Mutations in the Presenilin (PSEN1 and PSEN2) genes are the major cause of early-onset familial Alzheimer’s disease (FAD). Presenilin (PS) is the catalytic subunit of the γ-secretase complex, which cleaves type I transmembrane proteins, such as Notch and the amyloid precursor protein (APP), and play...

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Detalles Bibliográficos
Autores principales: Montenegro, Paola, Chen, Phoenix, Kang, Jongkyun, Lee, Sang Hun, Leone, Sofia, Shen, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589670/
https://www.ncbi.nlm.nih.gov/pubmed/37816062
http://dx.doi.org/10.1073/pnas.2306714120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589670/
https://www.ncbi.nlm.nih.gov/pubmed/37816062
http://dx.doi.org/10.1073/pnas.2306714120

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