Resistance mechanism to Notch inhibition and combination therapy in human T-cell acute lymphoblastic leukemia

Gain-of-function mutations in NOTCH1 are among the most frequent genetic alterations in T-cell acute lymphoblastic leukemia (T-ALL), highlighting the Notch signaling pathway as a promising therapeutic target for personalized medicine. Yet, a major limitation for long-term success of targeted therapy...

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Detalles Bibliográficos
Autores principales: Cao, Linlin, Ruiz Buendía, Gustavo A., Fournier, Nadine, Liu, Yuanlong, Armand, Florence, Hamelin, Romain, Pavlou, Maria, Radtke, Freddy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Lymphoid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589794/
https://www.ncbi.nlm.nih.gov/pubmed/37358480
http://dx.doi.org/10.1182/bloodadvances.2023010380

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589794/
https://www.ncbi.nlm.nih.gov/pubmed/37358480
http://dx.doi.org/10.1182/bloodadvances.2023010380

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