Development of super-specific epigenome editing by targeted allele-specific DNA methylation

BACKGROUND: Epigenome editing refers to the targeted reprogramming of genomic loci using an EpiEditor which may consist of an sgRNA/dCas9 complex that recruits DNMT3A/3L to the target locus. Methylation of the locus can lead to a modulation of gene expression. Allele-specific DNA methylation (ASM) r...

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Detalles Bibliográficos
Autores principales: Rajaram, Nivethika, Kouroukli, Alexandra G., Bens, Susanne, Bashtrykov, Pavel, Jeltsch, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589950/
https://www.ncbi.nlm.nih.gov/pubmed/37864244
http://dx.doi.org/10.1186/s13072-023-00515-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589950/
https://www.ncbi.nlm.nih.gov/pubmed/37864244
http://dx.doi.org/10.1186/s13072-023-00515-5

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