Cargando…

Development of super-specific epigenome editing by targeted allele-specific DNA methylation

BACKGROUND: Epigenome editing refers to the targeted reprogramming of genomic loci using an EpiEditor which may consist of an sgRNA/dCas9 complex that recruits DNMT3A/3L to the target locus. Methylation of the locus can lead to a modulation of gene expression. Allele-specific DNA methylation (ASM) r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rajaram, Nivethika, Kouroukli, Alexandra G., Bens, Susanne, Bashtrykov, Pavel, Jeltsch, Albert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Methodology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589950/ https://www.ncbi.nlm.nih.gov/pubmed/37864244 http://dx.doi.org/10.1186/s13072-023-00515-5

Ejemplares similares

Targeting oncogenic TERT promoter variants by allele-specific epigenome editing
por: Kouroukli, Alexandra G., et al.
Publicado: (2023)

The DNA methylation status of the TERT promoter differs between subtypes of mature B-cell lymphomas
por: Kouroukli, Alexandra G., et al.
Publicado: (2023)

Genome-wide investigation of the dynamic changes of epigenome modifications after global DNA methylation editing
por: Broche, Julian, et al.
Publicado: (2020)

Molecular Processes Connecting DNA Methylation Patterns with DNA Methyltransferases and Histone Modifications in Mammalian Genomes
por: Jeltsch, Albert, et al.
Publicado: (2018)

Molecular Processes Connecting DNA Methylation Patterns with DNA Methyltransferases and Histone Modifications in Mammalian Genomes
por: Jeltsch, Albert, et al.
Publicado: (2019)

Non-imprinted allele-specific DNA methylation on human autosomes
por: Zhang, Yingying, et al.
Publicado: (2009)

On the accuracy of the epigenetic copy machine: comprehensive specificity analysis of the DNMT1 DNA methyltransferase
por: Adam, Sabrina, et al.
Publicado: (2023)

Specificity of DNA triple helix formation analyzed by a FRET assay
por: Reither, Sabine, et al.
Publicado: (2002)

DAMEfinder: a method to detect differential allele-specific methylation
por: Orjuela, Stephany, et al.
Publicado: (2020)

Prediction of smoking by multiplex bisulfite PCR with long amplicons considering allele-specific effects on DNA methylation
por: Kondratyev, Nikolay, et al.
Publicado: (2018)

Engineering of Effector Domains for Targeted DNA Methylation with Reduced Off-Target Effects
por: Hofacker, Daniel, et al.
Publicado: (2020)

Editorial—Role of DNA Methyltransferases in the Epigenome
por: Jeltsch, Albert, et al.
Publicado: (2019)

Detection of allele-specific methylation through a generalized heterogeneous epigenome model
por: Peng, Qian, et al.
Publicado: (2012)

DNA methyltransferase DNMT3A forms interaction networks with the CpG site and flanking sequence elements for efficient methylation
por: Dukatz, Michael, et al.
Publicado: (2022)

Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase
por: Dukatz, Michael, et al.
Publicado: (2020)

DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation
por: Adam, Sabrina, et al.
Publicado: (2020)

Concurrent genome and epigenome editing by CRISPR-mediated sequence replacement
por: Alexander, Jes, et al.
Publicado: (2019)

Methylation of recombinant mononucleosomes by DNMT3A demonstrates efficient linker DNA methylation and a role of H3K36me3
por: Bröhm, Alexander, et al.
Publicado: (2022)

Efficient generation of epigenetic disease model mice by epigenome editing using the piggyBac transposon system
por: Horii, Takuro, et al.
Publicado: (2022)

Targeted epigenome editing of an endogenous locus with chromatin modifiers is not stably maintained
por: Kungulovski, Goran, et al.
Publicado: (2015)

Mutations of R882 change flanking sequence preferences of the DNA methyltransferase DNMT3A and cellular methylation patterns
por: Emperle, Max, et al.
Publicado: (2019)

Colorimetric detection of both total genomic and loci-specific DNA methylation from limited DNA inputs
por: Wee, Eugene J. H., et al.
Publicado: (2015)

Identification of protein lysine methylation readers with a yeast three-hybrid approach
por: Rawłuszko-Wieczorek, Agnieszka Anna, et al.
Publicado: (2018)

Bumblebee Workers Show Differences in Allele-Specific DNA Methylation and Allele-Specific Expression
por: Marshall, Hollie, et al.
Publicado: (2020)

Allele-specific expression assays using Solexa
por: Main, Bradley J, et al.
Publicado: (2009)

A novel methyl-binding domain protein enrichment method for identifying genome-wide tissue-specific DNA methylation from nanogram DNA samples
por: Oliver, Verity F, et al.
Publicado: (2013)

Structural and biochemical insight into the mechanism of dual CpG site binding and methylation by the DNMT3A DNA methyltransferase
por: Emperle, Max, et al.
Publicado: (2021)

Development and application of an integrated allele-specific pipeline for methylomic and epigenomic analysis (MEA)
por: Richard Albert, Julien, et al.
Publicado: (2018)

Leveraging locus-specific epigenetic heterogeneity to improve the performance of blood-based DNA methylation biomarkers
por: Miller, Brendan F., et al.
Publicado: (2020)

Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer
por: Heyn, Holger, et al.
Publicado: (2016)

Evaluating genome-wide DNA methylation changes in mice by Methylation Specific Digital Karyotyping
por: Boon, Kathy, et al.
Publicado: (2008)

An improved allele-specific PCR primer design method for SNP marker analysis and its application
por: Liu, Jing, et al.
Publicado: (2012)

Automating high-throughput screening for anthracnose resistance in common bean using allele specific PCR
por: Zaleski-Cox, Marysia, et al.
Publicado: (2023)

Tissue-specific patterns of allelically-skewed DNA methylation
por: Marzi, Sarah J., et al.
Publicado: (2016)

iASeq: integrative analysis of allele-specificity of protein-DNA interactions in multiple ChIP-seq datasets
por: Wei, Yingying, et al.
Publicado: (2012)

Analyzing allele specific RNA expression using mixture models
por: Lu, Rong, et al.
Publicado: (2015)

Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes
por: Li, Fuyang, et al.
Publicado: (2007)

Refined read‐out: The hUHRF1 Tandem‐Tudor domain prefers binding to histone H3 tails containing K4me1 in the context of H3K9me2/3
por: Choudalakis, Michel, et al.
Publicado: (2023)

Global epigenomic analysis indicates that Epialleles contribute to Allele-specific expression via Allele-specific histone modifications in hybrid rice
por: Guo, Zhibin, et al.
Publicado: (2015)

hsegHMM: hidden Markov model-based allele-specific copy number alteration analysis accounting for hypersegmentation
por: Choo-Wosoba, Hyoyoung, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_40bm2bq8rt6l549hhg1g2l0hff