Cargando…

Canagliflozin and irbesartan ameliorate renal fibrosis via the TGF-β1/Smad signaling pathway in Dahl salt-sensitive rats

OBJECTIVES: This study assessed the antifibrotic effects of canagliflozin, with or without irbesartan, on renal injury in Dahl salt-sensitive (SS) rats fed a high-salt (HS) diet. METHODS: After the preconditioning stage, Dahl SS rats (n = 47) were divided into five experimental groups as follows: lo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhai, Jianlong, Wang, Zhongli, Zhang, Tingting, He, Lili, Ma, Sai, Zuo, Qingjuan, Zhang, Guorui, Wang, Xinyu, Guo, Yifang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2023
Materias:	Pre-Clinical Research Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590049/ https://www.ncbi.nlm.nih.gov/pubmed/37862678 http://dx.doi.org/10.1177/03000605231206289

Ejemplares similares

An Effective Sodium-Dependent Glucose Transporter 2 Inhibition, Canagliflozin, Prevents Development of Hypertensive Heart Failure in Dahl Salt-Sensitive Rats
por: He, Lili, et al.
Publicado: (2022)

Canagliflozin Attenuates Hepatic Steatosis and Atherosclerosis Progression in Western Diet-Fed ApoE-Knockout Mice
por: Zuo, Qingjuan, et al.
Publicado: (2022)

Irbesartan ameliorates myocardial fibrosis in diabetic cardiomyopathy rats by inhibiting the TGFβ1/Smad2/3 pathway
por: Zong, Min, et al.
Publicado: (2020)

Mechanisms of pressure-diuresis and pressure-natriuresis in Dahl salt-resistant and Dahl salt-sensitive rats
por: Beard, Daniel A, et al.
Publicado: (2012)

Hypertonic Salt Solution Enhances Inflammatory Responses in Cultured Splenic T-Cells from Dahl Salt-Sensitive Rats but Not Dahl Salt-Resistant Rats
por: Jang, Sungmin, et al.
Publicado: (2023)

Lewis Dahl and the genetics of salt-induced hypertension
por: Bashyam, Hema
Publicado: (2007)

MiR-21 attenuates FAS-mediated cardiomyocyte apoptosis by regulating HIPK3 expression
por: Wang, Xinyu, et al.
Publicado: (2023)

Babao Dan inhibits the migration and invasion of gastric cancer cells by suppressing epithelial–mesenchymal transition through the TGF-β/Smad pathway
por: Liu, Jianxin, et al.
Publicado: (2020)

Activated pathogenic Th17 lymphocytes induce hypertension following high-fructose intake in Dahl salt-sensitive but not Dahl salt-resistant rats
por: Lee, Eunjo, et al.
Publicado: (2020)

Canagliflozin mitigates ferroptosis and ameliorates heart failure in rats with preserved ejection fraction
por: Ma, Sai, et al.
Publicado: (2022)

Genetic and dietary salt contributors to insulin resistance in Dahl salt-sensitive (S) rats
por: Shehata, Marlene
Publicado: (2008)

Effect of High Fat Loading in Dahl Salt-Sensitive Rats
por: Nagae, Ai, et al.
Publicado: (2009)

Effects of High Salt Intake on Detrusor Muscle Contraction in Dahl Salt-Sensitive Rats
por: Kawata, Ryoya, et al.
Publicado: (2021)

Important genetic checkpoints for insulin resistance in salt-sensitive (S) Dahl rats
por: Shehata, Marlene F
Publicado: (2008)

Renal sodium transport in renin-deficient Dahl salt-sensitive rats
por: Pavlov, Tengis S, et al.
Publicado: (2016)

Chronic cathepsin inhibition by E‐64 in Dahl salt‐sensitive rats
por: Blass, Gregory, et al.
Publicado: (2016)

Involvement of Vanin-1 in Ameliorating Effect of Oxidative Renal Tubular Injury in Dahl-Salt Sensitive Rats
por: Hosohata, Keiko, et al.
Publicado: (2019)

Roald Dahl’s contribution to neurosurgery: the Wade-Dahl-Till shunt
por: Buis, Dennis R., et al.
Publicado: (2010)

A multi-component model of the dynamics of salt-induced hypertension in Dahl-S rats
por: McLoone, Violeta I, et al.
Publicado: (2009)

GLUCOCORTICOIDS ACTIVATE CARDIAC MINERALOCORTICOID RECEPTORS IN ADRENALECTOMIZED DAHL SALT-SENSITIVE RATS
por: OHTAKE, MASAFUMI, et al.
Publicado: (2014)

Sodium Thiosulfate in the Pregnant Dahl Salt-Sensitive Rat, a Model of Preeclampsia
por: Terstappen, Fieke, et al.
Publicado: (2020)

Kcnj16 knockout produces audiogenic seizures in the Dahl salt-sensitive rat
por: Manis, Anna D., et al.
Publicado: (2021)

Salt-induced epithelial-to-mesenchymal transition in Dahl salt-sensitive rats is dependent on elevated blood pressure
por: Wang, Y., et al.
Publicado: (2014)

Amelioration of cardio-renal injury with aging in dahl salt-sensitive rats by H(2)-enriched electrolyzed water
por: Zhu, Wan-Jun, et al.
Publicado: (2013)

Effect of dietary salt intake on epithelial Na(+) channels (ENaCs) in the hypothalamus of Dahl salt‐sensitive rats
por: Mills, Natalie J., et al.
Publicado: (2018)

Natural sea salt consumption confers protection against hypertension and kidney damage in Dahl salt-sensitive rats
por: Lee, Bog-Hieu, et al.
Publicado: (2016)

(−)-Epigallocatechin-3-gallate (EGCG) attenuates salt-induced hypertension and renal injury in Dahl salt-sensitive rats
por: Luo, Dan, et al.
Publicado: (2020)

Revealing the Pathogenesis of Salt-Sensitive Hypertension in Dahl Salt-Sensitive Rats through Integrated Multi-Omics Analysis
por: Ou-Yang, Ya-nan, et al.
Publicado: (2022)

Irbesartan in experimental diabetic nephropathy
por: Mahajan, Rajiv, et al.
Publicado: (2010)

Role of the IRS-1 and/or -2 in the pathogenesis of insulin resistance in Dahl salt-sensitive (S) rats
por: Shehata, Marlene F.
Publicado: (2009)

Riociguat prevents fibrotic tissue remodelling and improves survival in salt-sensitive Dahl rats
por: Geschka, Sandra, et al.
Publicado: (2011)

Effect of Hypertension on the Occurrence of Micro-hemorrhage in the Pancreatic Islet of Dahl Salt-sensitive Rats
por: Imaoka, Masako, et al.
Publicado: (2012)

Renal Tumor Necrosis Factor α Contributes to Hypertension in Dahl Salt-Sensitive Rats
por: Huang, Baorui, et al.
Publicado: (2016)

Sex-specific genetic determinants for arterial stiffness in Dahl salt-sensitive hypertensive rats
por: Decano, Julius L., et al.
Publicado: (2016)

Dahl Salt-Resistant Rat Is Protected against Hypertension during Diet-Induced Obesity
por: Lee, Soyung, et al.
Publicado: (2022)

Effect of SGLT2 inhibition on salt-induced hypertension in female Dahl SS rats
por: Kravtsova, Olha, et al.
Publicado: (2023)

Renal Urotensin II System Plays Roles in the Regulation of Blood Pressure in Dahl Salt-Resistant Rat
por: Wu, Fei, et al.
Publicado: (2016)

High-Salt Intake Suppressed MicroRNA-133a Expression in Dahl SS Rat Myocardium
por: Guo, Tong-Shuai, et al.
Publicado: (2014)

Oxidative Stress-Induced Glomerular Mineralocorticoid Receptor Activation Limits the Benefit of Salt Reduction in Dahl Salt-Sensitive Rats
por: Kitada, Kento, et al.
Publicado: (2012)

Impact of High Salt Independent of Blood Pressure on PRMT/ADMA/DDAH Pathway in the Aorta of Dahl Salt-Sensitive Rats
por: Cao, Yu, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_5b85btd4m94ql5v0tm7c3mbqmp