Design and synthesis of cabotegravir derivatives bearing 1,2,3-triazole and evaluation of anti-liver cancer activity

Based on the structure of the anti-HIV drug cabotegravir, we introduced 1,2,3-triazole groups with different substituents to obtain 19 cabotegravir derivatives and tested their activity against HepG2 cells. The proliferation of HepG2 cells was examined following treatment with derivatives. Most of t...

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Detalles Bibliográficos
Autores principales: Xie, Huaxia, Mao, Longfei, Fan, Gaolu, Wu, Ziyuan, Wang, Yimian, Hou, Xixi, Wang, Jiangang, Wang, Huili, Liu, Ling, Li, Sanqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590056/
https://www.ncbi.nlm.nih.gov/pubmed/37869757
http://dx.doi.org/10.3389/fphar.2023.1265289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590056/
https://www.ncbi.nlm.nih.gov/pubmed/37869757
http://dx.doi.org/10.3389/fphar.2023.1265289

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