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Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice
A20 serves as a critical brake on NF-κB-dependent inflammation. In humans, polymorphisms in or near the TNFAIP3/A20 gene have been linked to various inflammatory disorders, including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Experimental gene knockout studies in mice have con...
Autores principales: | Van Damme, Karel F. A., Hertens, Pieter, Martens, Arne, Gilis, Elisabeth, Priem, Dario, Bruggeman, Inge, Fossoul, Amelie, Declercq, Jozefien, Aegerter, Helena, Wullaert, Andy, Hochepied, Tino, Hoste, Esther, Vande Walle, Lieselotte, Lamkanfi, Mohamed, Savvides, Savvas N., Elewaut, Dirk, Lambrecht, Bart N., van Loo, Geert |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590390/ https://www.ncbi.nlm.nih.gov/pubmed/37865713 http://dx.doi.org/10.1038/s41598-023-45324-8 |
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