Identification of dual STRN-NTRK2 rearrangements in a high grade sarcoma, with good clinical response to first-line larotrectinib therapy

BACKGROUND: Among the three NTRK genes, NTRK2 possesses a tremendous structural complexity and involves tumorigenesis of several types of tumors. To date, only STRN and RBPMS are identified in the fusion with NTRK2 in adult soft tissue tumors. More recently, the highly selective Trk tyrosine kinases...

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Detalles Bibliográficos
Autores principales: Lin, Ruihe, Mallick, Atrayee Basu, Wang, Zi-Xuan, Brown, Scot Andrew, Lu, Bo, Jiang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590500/
https://www.ncbi.nlm.nih.gov/pubmed/37865792
http://dx.doi.org/10.1186/s13000-023-01400-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590500/
https://www.ncbi.nlm.nih.gov/pubmed/37865792
http://dx.doi.org/10.1186/s13000-023-01400-1

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