A Drug–Drug Interaction Study to Evaluate the Impact of Simvastatin and Itraconazole on Erlotinib Pharmacokinetics in Rats by UPLC-MS/MS

AIM: The goal of our study was to investigate the effects of single-dose simvastatin and itraconazole application on the pharmacokinetics of erlotinib in rats. METHODS: Twenty-one male Sprague-Dawley rats were randomly divided into 3 groups, including erlotinib combined with simvastatin, erlotinib c...

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Detalles Bibliográficos
Autores principales: Fan, Zaiwen, Gao, Xiaonan, Wang, Mingxia, Tian, Ziqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590554/
https://www.ncbi.nlm.nih.gov/pubmed/37873519
http://dx.doi.org/10.2147/DDDT.S427213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590554/
https://www.ncbi.nlm.nih.gov/pubmed/37873519
http://dx.doi.org/10.2147/DDDT.S427213

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