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A Drug–Drug Interaction Study to Evaluate the Impact of Simvastatin and Itraconazole on Erlotinib Pharmacokinetics in Rats by UPLC-MS/MS

AIM: The goal of our study was to investigate the effects of single-dose simvastatin and itraconazole application on the pharmacokinetics of erlotinib in rats. METHODS: Twenty-one male Sprague-Dawley rats were randomly divided into 3 groups, including erlotinib combined with simvastatin, erlotinib c...

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Detalles Bibliográficos
Autores principales:	Fan, Zaiwen, Gao, Xiaonan, Wang, Mingxia, Tian, Ziqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590554/ https://www.ncbi.nlm.nih.gov/pubmed/37873519 http://dx.doi.org/10.2147/DDDT.S427213

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