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Pioglitazone-Loaded Cartilage-Targeted Nanomicelles (Pio@C-HA-DOs) for Osteoarthritis Treatment

BACKGROUND: Hyaluronic acid (HA) is a popular biological material for osteoarthritis (OA) treatment. Pioglitazone, a PPAR-γ agonist, has been found to inhibit OA, but its use is limited because achieving the desired local drug concentration after administration is challenging. PURPOSE: Herein, we co...

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Detalles Bibliográficos
Autores principales: Chen, Junyan, Xu, Wuyan, Dai, Tianming, Jiao, Songsong, Xue, Xiang, Jiang, Jiayang, Li, Siming, Meng, Qingqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590558/
https://www.ncbi.nlm.nih.gov/pubmed/37873552
http://dx.doi.org/10.2147/IJN.S428938