Hybrid insulin peptide isomers spontaneously form in pancreatic beta-cells from an aspartic anhydride intermediate

Hybrid insulin peptides (HIPs) form in beta-cells when insulin fragments link to other peptides through a peptide bond. HIPs contain nongenomic amino acid sequences and have been identified as targets for autoreactive T cells in type 1 diabetes. A subgroup of HIPs, in which N-terminal amine groups o...

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Detalles Bibliográficos
Autores principales: Crawford, Samantha A., Groegler, Jason, Dang, Mylinh, Michel, Cole, Powell, Roger L., Hohenstein, Anita C., Reyes, Kaitlin, Haskins, Kathryn, Wiles, Timothy A., Delong, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590738/
https://www.ncbi.nlm.nih.gov/pubmed/37734557
http://dx.doi.org/10.1016/j.jbc.2023.105264

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590738/
https://www.ncbi.nlm.nih.gov/pubmed/37734557
http://dx.doi.org/10.1016/j.jbc.2023.105264

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