Safety and effectiveness of HSK21542 for hemodialysis patients: a multiple ascending dose study

Background: HSK21542, a novel selective peripherally-restricted κ-opioid receptor agonist has been proven to be a safe and effective analgesic and antipruritic drug in both in vitro and in vivo studies. We aimed to evaluate its safety, pharmacokinetics and efficacy in hemodialysis patients over a 1-...

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Detalles Bibliográficos
Autores principales: Pan, Mingming, Wang, Guihua, Zhou, Li, Xu, Yan, Yao, Li, Wu, Chaoqing, Mei, Changlin, Zhao, Zhanzheng, Sun, Dong, Guan, Tianjun, Chen, Qinkai, Shi, Ming, Xu, Hui, Zeng, Weifang, Li, Fangqiong, Yan, Rui, Liu, Bi-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590914/
https://www.ncbi.nlm.nih.gov/pubmed/37876731
http://dx.doi.org/10.3389/fphar.2023.1203642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590914/
https://www.ncbi.nlm.nih.gov/pubmed/37876731
http://dx.doi.org/10.3389/fphar.2023.1203642

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