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Scn2a insufficiency alters spontaneous neuronal Ca(2+) activity in somatosensory cortex during wakefulness
SCN2A protein-truncating variants (PTV) can result in neurological disorders such as autism spectrum disorder and intellectual disability, but they are less likely to cause epilepsy in comparison to missense variants. While in vitro studies showed PTV reduce action potential firing, consequences at...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590963/ https://www.ncbi.nlm.nih.gov/pubmed/37876801 http://dx.doi.org/10.1016/j.isci.2023.108138 |