WIP1 is a novel specific target for growth hormone action

DNA damage repair (DDR) is mediated by phosphorylating effectors ATM kinase, CHK2, p53, and γH2AX. We showed earlier that GH suppresses DDR by suppressing pATM, resulting in DNA damage accumulation. Here, we show GH acting through GH receptor (GHR) inducing wild-type p53-inducible phosphatase 1 (WIP...

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Detalles Bibliográficos
Autores principales: Apaydin, Tugce, Zonis, Svetlana, Zhou, Cuiqi, Valencia, Christian Wong, Barrett, Robert, Strous, Ger J., Mol, Jan A., Chesnokova, Vera, Melmed, Shlomo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590974/
https://www.ncbi.nlm.nih.gov/pubmed/37876819
http://dx.doi.org/10.1016/j.isci.2023.108117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10590974/
https://www.ncbi.nlm.nih.gov/pubmed/37876819
http://dx.doi.org/10.1016/j.isci.2023.108117

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