Excessive concentrations of kinase inhibitors in translational studies impede effective drug repurposing

Drug repositioning seeks to leverage existing clinical knowledge to identify alternative clinical settings for approved drugs. However, repositioning efforts fail to demonstrate improved success rates in late-stage clinical trials. Focusing on 11 approved kinase inhibitors that have been evaluated i...

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Detalles Bibliográficos
Autores principales: Liu, Chuan, Leighow, Scott M., McIlroy, Kyle, Lu, Mengrou, Dennis, Kady A., Abello, Kerry, Brown, Donovan J., Moore, Connor J., Shah, Anushka, Inam, Haider, Rivera, Victor M., Pritchard, Justin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591048/
https://www.ncbi.nlm.nih.gov/pubmed/37852183
http://dx.doi.org/10.1016/j.xcrm.2023.101227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591048/
https://www.ncbi.nlm.nih.gov/pubmed/37852183
http://dx.doi.org/10.1016/j.xcrm.2023.101227

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