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Excessive concentrations of kinase inhibitors in translational studies impede effective drug repurposing
Drug repositioning seeks to leverage existing clinical knowledge to identify alternative clinical settings for approved drugs. However, repositioning efforts fail to demonstrate improved success rates in late-stage clinical trials. Focusing on 11 approved kinase inhibitors that have been evaluated i...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591048/ https://www.ncbi.nlm.nih.gov/pubmed/37852183 http://dx.doi.org/10.1016/j.xcrm.2023.101227 |