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Breaking barriers: NEK2 inhibition shines in multiple myeloma treatment
In their article, Cheng et al.(1) reveal that NEK2 loss reshapes the tumor microenvironment, reducing tumor-associated macrophages and decreasing T cell exhaustion. They show that this ultimately favors the immune system’s anti-cancer response in multiple myeloma.
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591060/ https://www.ncbi.nlm.nih.gov/pubmed/37852178 http://dx.doi.org/10.1016/j.xcrm.2023.101237 |
| _version_ | 1785124142828224512 |
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| author | Lischer, Christopher Bruns, Heiko |
| author_facet | Lischer, Christopher Bruns, Heiko |
| author_sort | Lischer, Christopher |
| collection | PubMed |
| description | In their article, Cheng et al.(1) reveal that NEK2 loss reshapes the tumor microenvironment, reducing tumor-associated macrophages and decreasing T cell exhaustion. They show that this ultimately favors the immune system’s anti-cancer response in multiple myeloma. |
| format | Online Article Text |
| id | pubmed-10591060 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-105910602023-10-24 Breaking barriers: NEK2 inhibition shines in multiple myeloma treatment Lischer, Christopher Bruns, Heiko Cell Rep Med Preview In their article, Cheng et al.(1) reveal that NEK2 loss reshapes the tumor microenvironment, reducing tumor-associated macrophages and decreasing T cell exhaustion. They show that this ultimately favors the immune system’s anti-cancer response in multiple myeloma. Elsevier 2023-10-17 /pmc/articles/PMC10591060/ /pubmed/37852178 http://dx.doi.org/10.1016/j.xcrm.2023.101237 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Preview Lischer, Christopher Bruns, Heiko Breaking barriers: NEK2 inhibition shines in multiple myeloma treatment |
| title | Breaking barriers: NEK2 inhibition shines in multiple myeloma treatment |
| title_full | Breaking barriers: NEK2 inhibition shines in multiple myeloma treatment |
| title_fullStr | Breaking barriers: NEK2 inhibition shines in multiple myeloma treatment |
| title_full_unstemmed | Breaking barriers: NEK2 inhibition shines in multiple myeloma treatment |
| title_short | Breaking barriers: NEK2 inhibition shines in multiple myeloma treatment |
| title_sort | breaking barriers: nek2 inhibition shines in multiple myeloma treatment |
| topic | Preview |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591060/ https://www.ncbi.nlm.nih.gov/pubmed/37852178 http://dx.doi.org/10.1016/j.xcrm.2023.101237 |
| work_keys_str_mv | AT lischerchristopher breakingbarriersnek2inhibitionshinesinmultiplemyelomatreatment AT brunsheiko breakingbarriersnek2inhibitionshinesinmultiplemyelomatreatment |