Cargando…

The Mechanism of Inhibition of Pyruvate Formate Lyase by Methacrylate

[Image: see text] Pyruvate Formate Lyase (PFL) catalyzes acetyl transfer from pyruvate to coenzyme a by a mechanism involving multiple amino acid radicals. A post-translationally installed glycyl radical (G(734)· in Escherichia coli) is essential for enzyme activity and two cysteines (C(418) and C(4...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cáceres, Juan Carlos, Dolmatch, August, Greene, Brandon L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591478/ https://www.ncbi.nlm.nih.gov/pubmed/37797332 http://dx.doi.org/10.1021/jacs.3c07256

Ejemplares similares

Physiological roles of pyruvate ferredoxin oxidoreductase and pyruvate formate-lyase in Thermoanaerobacterium saccharolyticum JW/SL-YS485
por: Zhou, Jilai, et al.
Publicado: (2015)

Pneumococcal galactose catabolism is controlled by multiple regulators acting on pyruvate formate lyase
por: Al-Bayati, Firas A. Y., et al.
Publicado: (2017)

Rescuing activity of oxygen-damaged pyruvate formate-lyase by a spare part protein
por: Andorfer, Mary C., et al.
Publicado: (2021)

Monovalent Cation Activation of the Radical SAM Enzyme Pyruvate Formate-Lyase Activating Enzyme
por: Shisler, Krista A., et al.
Publicado: (2017)

Computational engineering of previously crystallized pyruvate formate-lyase activating enzyme reveals insights into SAM binding and reductive cleavage
por: Moody, James D., et al.
Publicado: (2023)

Activation of Glycyl Radical Enzymes—Multiscale Modeling Insights into Catalysis and Radical Control in a Pyruvate Formate-Lyase-Activating Enzyme
por: Hanževački, Marko, et al.
Publicado: (2022)

N-acetylneuraminate pyruvate lyase controls sialylation of muscle glycoproteins essential for muscle regeneration and function
por: Da Silva, Afitz, et al.
Publicado: (2023)

Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation
por: Peleli, Maria, et al.
Publicado: (2023)

Co‑cultivation of the anaerobic fungus Caecomyces churrovis with Methanobacterium bryantii enhances transcription of carbohydrate binding modules, dockerins, and pyruvate formate lyases on specific substrates
por: Brown, Jennifer L., et al.
Publicado: (2021)

An E. coli biosensor for screening of cDNA libraries for isochorismate pyruvate lyase-encoding cDNAs
por: Zhou, Yingjie, et al.
Publicado: (2018)

Acrylic Functionalization of Cellulose Nanocrystals with 2-Isocyanatoethyl Methacrylate and Formation of Composites with Poly(methyl methacrylate)
por: Qu, Zihao, et al.
Publicado: (2020)

Chitin-Methacrylate: Preparation, Characterization and Hydrogel Formation
por: Khor, Eugene, et al.
Publicado: (2011)

Mechanisms of Inhibition of Rhizobium etli Pyruvate Carboxylase by l-Aspartate
por: Sirithanakorn, Chaiyos, et al.
Publicado: (2014)

Ethyl Pyruvate Induces Tolerogenic Dendritic Cells
por: Djedovic, Neda, et al.
Publicado: (2019)

(13)C Metabolic Flux Analysis Identifies an Unusual Route for Pyruvate Dissimilation in Mycobacteria which Requires Isocitrate Lyase and Carbon Dioxide Fixation
por: Beste, Dany J. V., et al.
Publicado: (2011)

Ethyl Pyruvate Emerges as a Safe and Fast Acting Agent against Trypanosoma brucei by Targeting Pyruvate Kinase Activity
por: Worku, Netsanet, et al.
Publicado: (2015)

Progesterone Receptor-Mediated Regulation of N-Acetylneuraminate Pyruvate Lyase (NPL) in Mouse Uterine Luminal Epithelium and Nonessential Role of NPL in Uterine Function
por: Xiao, Shuo, et al.
Publicado: (2013)

Tylosin Inhibits Streptococcus suis Biofilm Formation by Interacting With the O-acetylserine (thiol)-lyase B CysM
por: Zhou, Yonghui, et al.
Publicado: (2022)

Amphiphilic polysilane-methacrylate block copolymers — Formation and interesting properties —
por: Sakurai, Hideki
Publicado: (2006)

CyanoLyase: a database of phycobilin lyase sequences, motifs and functions
por: Bretaudeau, Anthony, et al.
Publicado: (2013)

Human Cystathionine γ-Lyase Is Inhibited by s-Nitrosation: A New Crosstalk Mechanism between NO and H(2)S
por: Fernandes, Dalila G. F., et al.
Publicado: (2021)

Adenylosuccinate lyase deficiency
por: Jurecka, Agnieszka, et al.
Publicado: (2014)

Enhanced ethanol formation by Clostridium thermocellum via pyruvate decarboxylase
por: Tian, Liang, et al.
Publicado: (2017)

Variation in Hydrogel Formation and Network Structure for Telo-, Atelo- and Methacrylated Collagens
por: Maher, Malachy Kevin, et al.
Publicado: (2022)

Enhancement of Inhibition of the Pseudomonas sp. Biofilm Formation on Bacterial Cellulose-Based Wound Dressing by the Combined Action of Alginate Lyase and Gentamicin
por: Charęza, Magdalena, et al.
Publicado: (2023)

Photocrosslinked Alginate-Methacrylate Hydrogels with Modulable Mechanical Properties: Effect of the Molecular Conformation and Electron Density of the Methacrylate Reactive Group
por: Araiza-Verduzco, Fernanda, et al.
Publicado: (2020)

Specific inhibition by synthetic analogs of pyruvate reveals that the pyruvate dehydrogenase reaction is essential for metabolism and viability of glioblastoma cells
por: Bunik, Victoria I., et al.
Publicado: (2015)

The anticoagulant effects of ethyl pyruvate in whole blood samples
por: Haidl, Harald, et al.
Publicado: (2020)

The roles of active site residues in the catalytic mechanism of methylaspartate ammonia-lyase()
por: Raj, Hans, et al.
Publicado: (2013)

The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier
por: Zangari, Joséphine, et al.
Publicado: (2020)

Mechanistic investigation of the formation of H(2) from HCOOH with a dinuclear Ru model complex for formate hydrogen lyase
por: Tokunaga, Taisuke, et al.
Publicado: (2017)

Screening of Alginate Lyase-Producing Bacteria and Optimization of Media Compositions for Extracellular Alginate Lyase Production
por: Tavafi, Hadis, et al.
Publicado: (2017)

Substrate Binding in the FAD-Dependent Hydroxynitrile Lyase from Almond Provides Insight into the Mechanism of Cyanohydrin Formation and Explains the Absence of Dehydrogenation Activity(,)
por: Dreveny, Ingrid, et al.
Publicado: (2009)

Hypoxia increases persulfide and polysulfide formation by AMP kinase dependent cystathionine gamma lyase phosphorylation
por: Alam, Shafiul, et al.
Publicado: (2023)

Structural Basis of the Inhibition of L-Methionine γ-Lyase from Fusobacterium nucleatum
por: Bu, Tingting, et al.
Publicado: (2023)

Poly(trehalose methacrylate) as an Excipient for Insulin Stabilization: Mechanism and Safety
por: Gelb, Madeline B., et al.
Publicado: (2022)

New Insights on the Mechanism of the K(+)-Independent Activity of Crenarchaeota Pyruvate Kinases
por: De la Vega-Ruíz, Gustavo, et al.
Publicado: (2015)

Screening of a Novel Polysaccharide Lyase Family 10 Pectate Lyase from Paenibacillus polymyxa KF-1: Cloning, Expression and Characterization
por: Zhao, Yan, et al.
Publicado: (2018)

Recalcitrant cell wall of Ulva lactuca seaweed is degraded by a single ulvan lyase from family 25 of polysaccharide lyases
por: Costa, Mónica M., et al.
Publicado: (2022)

Prevalence of adenylosuccinate lyase deficiency based on aggregated exome data
por: Ferreira, Carlos R.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_bb7dju8b6bj9sls4r1q8k2l7mg