Mechanism and evolutionary origins of alanine-tail C-degron recognition by E3 ligases Pirh2 and CRL2-KLHDC10

In ribosome-associated quality control (RQC), nascent polypeptides produced by interrupted translation are modified with C-terminal polyalanine tails (“Ala-tails”) that function outside ribosomes to induce ubiquitylation by E3 ligases Pirh2 (p53-induced RING-H2 domain-containing) or CRL2 (Cullin-2 R...

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Detalles Bibliográficos
Autores principales: Patil, Pratik Rajendra, Burroughs, A. Maxwell, Misra, Mohit, Cerullo, Federico, Costas-Insua, Carlos, Hung, Hao-Chih, Dikic, Ivan, Aravind, L., Joazeiro, Claudio A.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591846/
https://www.ncbi.nlm.nih.gov/pubmed/37676773
http://dx.doi.org/10.1016/j.celrep.2023.113100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591846/
https://www.ncbi.nlm.nih.gov/pubmed/37676773
http://dx.doi.org/10.1016/j.celrep.2023.113100

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