Comprehensive synergy mapping links a BAF- and NSL-containing “supercomplex” to the transcriptional silencing of HIV-1

Host repressors mediate HIV latency, but how they interactively silence the virus remains unclear. Here, we develop “reiterative enrichment and authentication of CRISPRi targets for synergies (REACTS)” to probe the genome for synergies between HIV transcription repressors. Using eight known host rep...

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Detalles Bibliográficos
Autores principales: Li, Zichong, Deeks, Steven G., Ott, Melanie, Greene, Warner C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591912/
https://www.ncbi.nlm.nih.gov/pubmed/37682714
http://dx.doi.org/10.1016/j.celrep.2023.113055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591912/
https://www.ncbi.nlm.nih.gov/pubmed/37682714
http://dx.doi.org/10.1016/j.celrep.2023.113055

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