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Multiscale model of primary motor cortex circuits predicts in vivo cell-type-specific, behavioral state-dependent dynamics

Understanding cortical function requires studying multiple scales: molecular, cellular, circuit, and behavioral. We develop a multiscale, biophysically detailed model of mouse primary motor cortex (M1) with over 10,000 neurons and 30 million synapses. Neuron types, densities, spatial distributions,...

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Detalles Bibliográficos
Autores principales: Dura-Bernal, Salvador, Neymotin, Samuel A., Suter, Benjamin A., Dacre, Joshua, Moreira, Joao V.S., Urdapilleta, Eugenio, Schiemann, Julia, Duguid, Ian, Shepherd, Gordon M.G., Lytton, William W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592234/
https://www.ncbi.nlm.nih.gov/pubmed/37300831
http://dx.doi.org/10.1016/j.celrep.2023.112574