Small molecule targeting of transcription-replication conflict for selective chemotherapy

Targeting transcription replication conflicts, a major source of endogenous DNA double-stranded breaks and genomic instability could have important anticancer therapeutic implications. Proliferating cell nuclear antigen (PCNA) is critical to DNA replication and repair processes. Through a rational d...

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Detalles Bibliográficos
Autores principales: Gu, Long, Li, Min, Li, Caroline M., Haratipour, Pouya, Lingeman, Robert, Jossart, Jennifer, Gutova, Margarita, Flores, Linda, Hyde, Caitlyn, Kenjić, Nikola, Li, Haiqing, Chung, Vincent, Li, Hongzhi, Lomenick, Brett, Von Hoff, Daniel D., Synold, Timothy W., Aboody, Karen S., Liu, Yilun, Horne, David, Hickey, Robert J., Perry, J. Jefferson P., Malkas, Linda H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592352/
https://www.ncbi.nlm.nih.gov/pubmed/37531956
http://dx.doi.org/10.1016/j.chembiol.2023.07.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592352/
https://www.ncbi.nlm.nih.gov/pubmed/37531956
http://dx.doi.org/10.1016/j.chembiol.2023.07.001

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