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Mutant IDH regulates glycogen metabolism from early cartilage development to malignant chondrosarcoma formation
Chondrosarcomas are the most common malignancy of cartilage and are associated with somatic mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 genes. Somatic IDH mutations are also found in its benign precursor lesion, enchondromas, suggesting that IDH mutations are early events in malignant tr...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592452/ https://www.ncbi.nlm.nih.gov/pubmed/37267108 http://dx.doi.org/10.1016/j.celrep.2023.112578 |