Mutant IDH regulates glycogen metabolism from early cartilage development to malignant chondrosarcoma formation

Chondrosarcomas are the most common malignancy of cartilage and are associated with somatic mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 genes. Somatic IDH mutations are also found in its benign precursor lesion, enchondromas, suggesting that IDH mutations are early events in malignant tr...

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Detalles Bibliográficos
Autores principales: Pathmanapan, Sinthu, Poon, Raymond, De Renshaw, Tomasa Barrientos, Nadesan, Puviindran, Nakagawa, Makoto, Seesankar, Gireesh A., Loe, Adrian Kwan Ho, Zhang, Hongyuan H., Guinovart, Joan J., Duran, Jordi, Newgard, Christopher B., Wunder, Jay S., Alman, Benjamin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592452/
https://www.ncbi.nlm.nih.gov/pubmed/37267108
http://dx.doi.org/10.1016/j.celrep.2023.112578

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