VIP interneuron impairment promotes in vivo circuit dysfunction and autism-related behaviors in Dravet syndrome

Dravet syndrome (DS) is a severe neurodevelopmental disorder caused by loss-of-function variants in SCN1A, which encodes the voltage-gated sodium channel subunit Nav1.1. We recently showed that neocortical vasoactive intestinal peptide interneurons (VIP-INs) express Nav1.1 and are hypoexcitable in D...

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Detalles Bibliográficos
Autores principales: Goff, Kevin M., Liebergall, Sophie R., Jiang, Evan, Somarowthu, Ala, Goldberg, Ethan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592464/
https://www.ncbi.nlm.nih.gov/pubmed/37310860
http://dx.doi.org/10.1016/j.celrep.2023.112628

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592464/
https://www.ncbi.nlm.nih.gov/pubmed/37310860
http://dx.doi.org/10.1016/j.celrep.2023.112628

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