The adhesion GPCRs CELSR1–3 and LPHN3 engage G proteins via distinct activation mechanisms

Adhesion G protein-coupled receptors (aGPCRs) are a large GPCR class that direct diverse fundamental biological processes. One prominent mechanism for aGPCR agonism involves autoproteolytic cleavage, which generates an activating, membrane-proximal tethered agonist (TA). How universal this mechanism...

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Detalles Bibliográficos
Autores principales: Bui, Duy Lan Huong, Roach, Andrew, Li, Jingxian, Bandekar, Sumit J., Orput, Elizabeth, Raghavan, Ritika, Araç, Demet, Sando, Richard C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592476/
https://www.ncbi.nlm.nih.gov/pubmed/37224017
http://dx.doi.org/10.1016/j.celrep.2023.112552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592476/
https://www.ncbi.nlm.nih.gov/pubmed/37224017
http://dx.doi.org/10.1016/j.celrep.2023.112552

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