FORMATION OF MALIGNANT, METASTATIC SMALL CELL LUNG CANCERS THROUGH OVERPRODUCTION OF cMYC PROTEIN IN TP53 AND RB1 DEPLETED PULMONARY NEUROENDOCRINE CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS

We recently described our initial efforts to develop a model for small cell lung cancer (SCLC) derived from human embryonic stem cells (hESCs) that were differentiated to form pulmonary neuroendocrine cells (PNECs), a putative cell of origin for neuroendocrine-positive SCLC. Although reduced express...

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Detalles Bibliográficos
Autores principales: Chen, Huanhuan Joyce, Gardner, Eric E., Shah, Yajas, Zhang, Kui, Thakur, Abhimanyu, Zhang, Chen, Elemento, Olivier, Varmus, Harold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592623/
https://www.ncbi.nlm.nih.gov/pubmed/37873210
http://dx.doi.org/10.1101/2023.10.06.561244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592623/
https://www.ncbi.nlm.nih.gov/pubmed/37873210
http://dx.doi.org/10.1101/2023.10.06.561244

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