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Functional genomics reveals an off-target dependency of drug synergy in gastric cancer therapy

The rational combination of anticancer agents is critical to improving patient outcomes in cancer. Nonetheless, most combination regimens in the clinic result from empirical methodologies disregarding insight into the mechanism of action and missing the opportunity to improve therapy outcomes increm...

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Detalles Bibliográficos
Autores principales: Leylek, Ozen, Honeywell, Megan E., Lee, Michael J., Hemann, Michael T., Ozcan, Gulnihal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592690/
https://www.ncbi.nlm.nih.gov/pubmed/37873383
http://dx.doi.org/10.1101/2023.10.07.561351