Genetic and pharmacologic alterations of claudin9 levels suffice to induce functional and mature inner hair cells

Hearing loss is the most common form of sensory deficit. It occurs predominantly due to hair cell (HC) loss. Mammalian HCs are terminally differentiated by birth, making HC loss incurable. Here, we show the pharmacogenetic downregulation of Cldn9, a tight junction protein, generates robust supernume...

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Detalles Bibliográficos
Autores principales: Chen, Yingying, Lee, Jeong Han, Li, Jin, Park, Seojin, Flores, Maria C. Perez, Peguero, Braulio, Kersigo, Jennifer, Kang, Mincheol, Choi, Jinsil, Levine, Lauren, Gratton, Michael Anne, Fritzsch, Bernd, Yamoah, Ebenezer N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592694/
https://www.ncbi.nlm.nih.gov/pubmed/37873357
http://dx.doi.org/10.1101/2023.10.08.561387

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592694/
https://www.ncbi.nlm.nih.gov/pubmed/37873357
http://dx.doi.org/10.1101/2023.10.08.561387

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