Cargando…

Genetic and pharmacologic alterations of claudin9 levels suffice to induce functional and mature inner hair cells

Hearing loss is the most common form of sensory deficit. It occurs predominantly due to hair cell (HC) loss. Mammalian HCs are terminally differentiated by birth, making HC loss incurable. Here, we show the pharmacogenetic downregulation of Cldn9, a tight junction protein, generates robust supernume...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Yingying, Lee, Jeong Han, Li, Jin, Park, Seojin, Flores, Maria C. Perez, Peguero, Braulio, Kersigo, Jennifer, Kang, Mincheol, Choi, Jinsil, Levine, Lauren, Gratton, Michael Anne, Fritzsch, Bernd, Yamoah, Ebenezer N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592694/ https://www.ncbi.nlm.nih.gov/pubmed/37873357 http://dx.doi.org/10.1101/2023.10.08.561387

Ejemplares similares

Inner ear hair cells deteriorate in mice engineered to have no or diminished innervation
por: Kersigo, Jennifer, et al.
Publicado: (2015)

The Piezo channel is central to the mechano-sensitive channel complex in the mammalian inner ear
por: Lee, Jeong Han, et al.
Publicado: (2023)

Neurod1 Suppresses Hair Cell Differentiation in Ear Ganglia and Regulates Hair Cell Subtype Development in the Cochlea
por: Jahan, Israt, et al.
Publicado: (2010)

Sustained Loss of Bdnf Affects Peripheral but Not Central Vestibular Targets
por: Elliott, Karen L., et al.
Publicado: (2021)

Developmental Changes in Peripherin-eGFP Expression in Spiral Ganglion Neurons
por: Elliott, Karen L., et al.
Publicado: (2021)

Early Deletion of Neurod1 Alters Neuronal Lineage Potential and Diminishes Neurogenesis in the Inner Ear
por: Filova, Iva, et al.
Publicado: (2022)

Neurog1, Neurod1, and Atoh1 are essential for spiral ganglia, cochlear nuclei, and cochlear hair cell development
por: Elliott, Karen L, et al.
Publicado: (2021)

Prickle1 regulates neurite outgrowth of apical spiral ganglion neurons but not hair cell polarity in the murine cochlea
por: Yang, Tian, et al.
Publicado: (2017)

Cisplatin Neurotoxicity Targets Specific Subpopulations and K(+) Channels in Tyrosine-Hydroxylase Positive Dorsal Root Ganglia Neurons
por: Finno, Carrie J., et al.
Publicado: (2022)

The local translation of K(Na) in dendritic projections of auditory neurons and the roles of K(Na) in the transition from hidden to overt hearing loss
por: Lee, Jeong Han, et al.
Publicado: (2019)

A Novel Atoh1 “Self-Terminating” Mouse Model Reveals the Necessity of Proper Atoh1 Level and Duration for Hair Cell Differentiation and Viability
por: Pan, Ning, et al.
Publicado: (2012)

The Development of Speaking and Singing in Infants May Play a Role in Genomics and Dementia in Humans
por: Yamoah, Ebenezer N., et al.
Publicado: (2023)

Topologically correct central projections of tetrapod inner ear afferents require Fzd3
por: Duncan, Jeremy S., et al.
Publicado: (2019)

Neurosensory development of the four brainstem-projecting sensory systems and their integration in the telencephalon
por: Fritzsch, Bernd, et al.
Publicado: (2022)

Age-Related Hearing Loss: Sensory and Neural Etiology and Their Interdependence
por: Elliott, Karen L., et al.
Publicado: (2022)

Rick Horwitz: Words do not suffice
por: Sedwick, Caitlin
Publicado: (2015)

Combining Lipophilic dye, in situ Hybridization, Immunohistochemistry, and Histology
por: Duncan, Jeremy, et al.
Publicado: (2011)

Does an Old Art Suffice for New Problems?
por: Swierstra, Tsjalling
Publicado: (2015)

Development in the Mammalian Auditory System Depends on Transcription Factors
por: Elliott, Karen L., et al.
Publicado: (2021)

Disentangling diatom species complexes: does morphometry suffice?
por: Blanco, Saúl, et al.
Publicado: (2017)

Nonfasting Lipid Profile May Suffice to Manage Dyslipidemia
por: Andrade, Chittaranjan
Publicado: (2020)

Does suffering suffice? An experimental assessment of desert retributivism
por: Bauer, Paul C., et al.
Publicado: (2020)

Why Does the Precautionary Principle Suffice for Blood Regulation?
por: Seifner, Alexandra, et al.
Publicado: (2021)

Spiral Ganglion Neuron Projection Development to the Hindbrain in Mice Lacking Peripheral and/or Central Target Differentiation
por: Elliott, Karen L., et al.
Publicado: (2017)

The Activity of Spontaneous Action Potentials in Developing Hair Cells Is Regulated by Ca(2+)-Dependence of a Transient K(+) Current
por: Levic, Snezana, et al.
Publicado: (2011)

Early functional alterations in membrane properties and neuronal degeneration are hallmarks of progressive hearing loss in NOD mice
por: Lee, Jeong Han, et al.
Publicado: (2019)

Regeneration of Hair Cells: Making Sense of All the Noise
por: Kopecky, Benjamin, et al.
Publicado: (2011)

Gata3 is required for the functional maturation of inner hair cells and their innervation in the mouse cochlea
por: Bardhan, Tanaya, et al.
Publicado: (2019)

Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation
por: Corns, Laura F., et al.
Publicado: (2018)

Sensory transduction is required for normal development and maturation of cochlear inner hair cell synapses
por: Lee, John, et al.
Publicado: (2021)

Correction: The Activity of Spontaneous Action Potentials in Developing Hair Cells Is Regulated by Ca(2+)-Dependence of a Transient K(+) Current
por: Levic, Snezana, et al.
Publicado: (2013)

Short pyrosequencing reads suffice for accurate microbial community analysis
por: Liu, Zongzhi, et al.
Publicado: (2007)

A Few Stickleback Suffice for the Transport of Alleles to New Lakes
por: Galloway, Jared, et al.
Publicado: (2019)

Dose Coronary Angiography Suffice for Assessment of Intermediate Coronary Stenosis?
por: Ahn, Sung Gyun, et al.
Publicado: (2019)

Melanotic Neuroectodermal Tumor of Infancy: Does Enucleation Alone Suffice?
por: Zameer, M. M., et al.
Publicado: (2021)

Global control of COVID-19: good vaccines may not suffice
por: Eslava-Schmalbach, Javier, et al.
Publicado: (2021)

The central clock suffices to drive the majority of circulatory metabolic rhythms
por: Petrus, Paul, et al.
Publicado: (2022)

Single-Cell RNA-seq Reveals Profound Alterations in Mechanosensitive Dorsal Root Ganglion Neurons with Vitamin E Deficiency
por: Finno, Carrie J., et al.
Publicado: (2019)

Tight Junction barriers in human hair follicles – role of claudin-1
por: Zorn-Kruppa, Michaela, et al.
Publicado: (2018)

Claudin h Is Essential for Hair Cell Morphogenesis and Auditory Function in Zebrafish
por: Gong, Jie, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_8dn9fppumm12s151qat1smbt6q