Histone H3 E50K mutation confers oncogenic activity and supports an EMT phenotype

Sequencing of human patient tumors has identified recurrent missense mutations in genes encoding core histones. We report that mutations that convert histone H3 amino acid 50 from a glutamate to a lysine (H3E50K) support an oncogenic phenotype in human cells. Expression of H3E50K is sufficient to tr...

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Detalles Bibliográficos
Autores principales: Sad, K, Jones, CY, Adams, M, Lustenberger, S, Lee, RS, Elayavalli, SR, Farhi, J, Lemon, LD, Fasken, MB, Corbett, AH, Spangle, JM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592736/
https://www.ncbi.nlm.nih.gov/pubmed/37873162
http://dx.doi.org/10.1101/2023.10.11.561775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592736/
https://www.ncbi.nlm.nih.gov/pubmed/37873162
http://dx.doi.org/10.1101/2023.10.11.561775

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