Cargando…

Identification of a binding site for bupropion in Gloeobacter violaceus ligand-gated ion channel

Bupropion is an atypical antidepressant and smoking cessation drug which causes adverse effects such as insomnia, irritability, and anxiety. Bupropion inhibits dopamine and norepinephrine reuptake transporters and eukaryotic cation-conducting pentameric ligand-gated ion channels (pLGICs), such as ni...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pirayesh, Elham, Do, Hoa Quynh, Ferreira, Garren, Pandhare, Akash, Gallardo, Zackary Ryan, Jansen, Michaela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592773/ https://www.ncbi.nlm.nih.gov/pubmed/37873398 http://dx.doi.org/10.1101/2023.10.09.561596

Ejemplares similares

Perturbation of Critical Prolines in Gloeobacter violaceus Ligand-gated Ion Channel (GLIC) Supports Conserved Gating Motions among Cys-loop Receptors
por: Rienzo, Matthew, et al.
Publicado: (2016)

Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel
por: Nemecz, Ákos, et al.
Publicado: (2017)

The Role of Selected Wavelengths of Light in the Activity of Photosystem II in Gloeobacter violaceus
por: Kula-Maximenko, Monika, et al.
Publicado: (2021)

A membrane-embedded pathway delivers general anesthetics to two interacting binding sites in the Gloeobacter violaceus ion channel
por: Arcario, Mark J., et al.
Publicado: (2017)

Establishment of the reporter system for a thylakoid-lacking cyanobacterium, Gloeobacter violaceus PCC 7421
por: Araki, Mie, et al.
Publicado: (2012)

Structural basis for the absence of low-energy chlorophylls in a photosystem I trimer from Gloeobacter violaceus
por: Kato, Koji, et al.
Publicado: (2022)

Triple arginines as molecular determinants for pentameric assembly of the intracellular domain of 5-HT(3A) receptors
por: Pandhare, Akash, et al.
Publicado: (2019)

Bupropion Inhibits Serotonin Type 3AB Heteromeric Channels at Clinically Relevant Concentrations
por: Stuebler, Antonia G., et al.
Publicado: (2020)

Painful violaceus bullae of the hands
por: Kollman, Natalie, et al.
Publicado: (2019)

X-ray Crystallographic Structure and Oligomerization of Gloeobacter Rhodopsin
por: Morizumi, Takefumi, et al.
Publicado: (2019)

Interplay between Gating and Block of Ligand-Gated Ion Channels
por: Phillips, Matthew B., et al.
Publicado: (2020)

Reference genome of the Monkeyface Prickleback, Cebidichthys violaceus
por: Wright, Daniel B, et al.
Publicado: (2022)

Allosteric coupling in ligand-gated ion channels
por: Colquhoun, David, et al.
Publicado: (2012)

Effects of cannabinoids on ligand-gated ion channels
por: Oz, Murat, et al.
Publicado: (2022)

A phylogenetically novel cyanobacterium most closely related to Gloeobacter
por: Grettenberger, Christen L., et al.
Publicado: (2020)

Ligand Activation of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC
por: Zimmermann, Iwan, et al.
Publicado: (2011)

The complete mitochondrial genome of Pseudocolochirus violaceus (Cucumariidae, Dendrochirotida)
por: Wang, Yan, et al.
Publicado: (2020)

The complete mitochondrial genome and phylogenetic analysis of Spondylus violaceus
por: Liu, Fuyun, et al.
Publicado: (2019)

Fast functional mapping of ligand-gated ion channels
por: Schmauder, Ralf, et al.
Publicado: (2023)

Pentameric quaternary structure of the intracellular domain of serotonin type 3A receptors
por: Pandhare, Akash, et al.
Publicado: (2016)

Functional importance of the oligomer formation of the cyanobacterial H(+) pump Gloeobacter rhodopsin
por: Iizuka, Azusa, et al.
Publicado: (2019)

Extracellular protons titrate voltage gating of a ligand-gated ion channel
por: Martínez-François, Juan Ramón, et al.
Publicado: (2010)

Stereoselective Metabolism of Bupropion to OH-bupropion, Threohydrobupropion, Erythrohydrobupropion, and 4′-OH-bupropion in vitro
por: Sager, Jennifer E., et al.
Publicado: (2016)

Molecular Simulations of Hydrophobic Gating of Pentameric Ligand Gated Ion Channels: Insights into Water and Ions
por: Rao, Shanlin, et al.
Publicado: (2021)

Naltrexone/Bupropion: Contrave®; Naltrexone SR/Bupropion SR
Publicado: (2012)

Functional Modifications of Acid-Sensing Ion Channels by Ligand-Gated Chloride Channels
por: Chen, Xuanmao, et al.
Publicado: (2011)

Phylogenomics of Ligand-Gated Ion Channels Predicts Monepantel Effect
por: Rufener, Lucien, et al.
Publicado: (2010)

Ligand-gated ion channel interacting proteins and their role in neuroprotection
por: Li, Shupeng, et al.
Publicado: (2014)

Signal Transduction Pathways in the Pentameric Ligand-Gated Ion Channels
por: Mowrey, David, et al.
Publicado: (2013)

Amphetamine activates/potentiates a ligand-gated ion channel
por: Carvelli, Lucia
Publicado: (2014)

Ligand-Gated Ion Channels as Targets for Treatment and Management of Cancers
por: Rao, Rohan, et al.
Publicado: (2022)

Derepression may masquerade as activation in ligand-gated ion channels
por: Tessier, Christian J. G., et al.
Publicado: (2023)

Ligand-Gated Ion Channels: Prognostic and Therapeutic Implications for Gliomas
por: Hey, Grace, et al.
Publicado: (2023)

Acute Dystonia After Single Dose of Bupropion
por: Elyasi, Forouzan, et al.
Publicado: (2016)

Binding motif for RIC-3 chaperon protein in serotonin type 3A receptors
por: Do, Hoa Quynh, et al.
Publicado: (2023)

The Primitive Thylakoid-Less Cyanobacterium Gloeobacter Is a Common Rock-Dwelling Organism
por: Mareš, Jan, et al.
Publicado: (2013)

Functional Expression of Gloeobacter Rhodopsin in PSI-Less Synechocystis sp. PCC6803
por: Chen, Que, et al.
Publicado: (2019)

Molecular Mingling: Multimodal Predictions of Ligand Promiscuity in Pentameric Ligand-Gated Ion Channels
por: Koniuszewski, Filip, et al.
Publicado: (2022)

Site-Directed Spin Labeling Reveals Pentameric Ligand-Gated Ion Channel Gating Motions
por: Dellisanti, Cosma D., et al.
Publicado: (2013)

Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels
por: Sauguet, Ludovic, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_8k88ovkk2flh9tba6fcojd97jm