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Measuring conformational equilibria in allosteric proteins with time-resolved tmFRET

Proteins are the workhorses of biology, orchestrating a myriad of cellular functions through intricate conformational changes. Protein allostery, the phenomenon where binding of ligands or environmental changes induce conformational rearrangements in the protein, is fundamental to these processes. W...

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Detalles Bibliográficos
Autores principales: Zagotta, William N., Evans, Eric G. B., Eggan, Pierce, Tessmer, Maxx H., Shaffer, Kyle D., Petersson, E. James, Stoll, Stefan, Gordon, Sharona E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592786/
https://www.ncbi.nlm.nih.gov/pubmed/37873384
http://dx.doi.org/10.1101/2023.10.09.561594