The H3.3 K36M oncohistone disrupts the establishment of epigenetic memory through loss of DNA methylation

Histone H3.3 is frequently mutated in cancers, with the lysine 36 to methionine mutation (K36M) being a hallmark of chondroblastomas. While it is known that H3.3K36M changes the cellular epigenetic landscape, it remains unclear how it affects the dynamics of gene expression. Here, we use a synthetic...

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Detalles Bibliográficos
Autores principales: Sinha, Joydeb, Nickels, Jan F., Thurm, Abby R., Ludwig, Connor H., Archibald, Bella N., Hinks, Michaela M., Wan, Jun, Fang, Dong, Bintu, Lacramioara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592807/
https://www.ncbi.nlm.nih.gov/pubmed/37873347
http://dx.doi.org/10.1101/2023.10.13.562147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592807/
https://www.ncbi.nlm.nih.gov/pubmed/37873347
http://dx.doi.org/10.1101/2023.10.13.562147

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