Reprogramming megakaryocytes to engineer platelets as delivery vehicles

We developed a method for the efficient generation of engineered platelets that can be filled with any recombinant therapeutic protein during the differentiation process by reprogramming megakaryocytes, the progenitor cells of platelets. To demonstrate the versatility of this approach, we loaded cyt...

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Detalles Bibliográficos
Autores principales: Javdan, Shwan B., Islam, Farhana, Deans, Tara L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592833/
https://www.ncbi.nlm.nih.gov/pubmed/37873465
http://dx.doi.org/10.1101/2023.10.13.562311
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author Javdan, Shwan B.
Islam, Farhana
Deans, Tara L.
author_facet Javdan, Shwan B.
Islam, Farhana
Deans, Tara L.
author_sort Javdan, Shwan B.
collection PubMed
description We developed a method for the efficient generation of engineered platelets that can be filled with any recombinant therapeutic protein during the differentiation process by reprogramming megakaryocytes, the progenitor cells of platelets. To demonstrate the versatility of this approach, we loaded cytoplasmic and secreted proteins that can be delivered as active enzymes to recipient cells, be released upon platelet activation, or be continuously secreted by platelets over time.
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spelling pubmed-105928332023-10-24 Reprogramming megakaryocytes to engineer platelets as delivery vehicles Javdan, Shwan B. Islam, Farhana Deans, Tara L. bioRxiv Article We developed a method for the efficient generation of engineered platelets that can be filled with any recombinant therapeutic protein during the differentiation process by reprogramming megakaryocytes, the progenitor cells of platelets. To demonstrate the versatility of this approach, we loaded cytoplasmic and secreted proteins that can be delivered as active enzymes to recipient cells, be released upon platelet activation, or be continuously secreted by platelets over time. Cold Spring Harbor Laboratory 2023-10-14 /pmc/articles/PMC10592833/ /pubmed/37873465 http://dx.doi.org/10.1101/2023.10.13.562311 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Javdan, Shwan B.
Islam, Farhana
Deans, Tara L.
Reprogramming megakaryocytes to engineer platelets as delivery vehicles
title Reprogramming megakaryocytes to engineer platelets as delivery vehicles
title_full Reprogramming megakaryocytes to engineer platelets as delivery vehicles
title_fullStr Reprogramming megakaryocytes to engineer platelets as delivery vehicles
title_full_unstemmed Reprogramming megakaryocytes to engineer platelets as delivery vehicles
title_short Reprogramming megakaryocytes to engineer platelets as delivery vehicles
title_sort reprogramming megakaryocytes to engineer platelets as delivery vehicles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592833/
https://www.ncbi.nlm.nih.gov/pubmed/37873465
http://dx.doi.org/10.1101/2023.10.13.562311
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