C5aR1 signaling promotes region and age dependent synaptic pruning in models of Alzheimer’s Disease

INTRODUCTION: Synaptic loss is a hallmark of Alzheimer’s disease (AD) that correlates with cognitive decline in AD patients. Complement-mediated synaptic pruning has been associated with this excessive loss of synapses in AD. Here, we investigated the effect of C5aR1 inhibition on microglial and ast...

Descripción completa

Detalles Bibliográficos
Autores principales: Gomez-Arboledas, Angela, Fonseca, Maria I., Kramar, Enikö, Chu, Shu-Hui, Schartz, Nicole, Selvan, Purnika, Wood, Marcelo A., Tenner, Andrea J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592845/
https://www.ncbi.nlm.nih.gov/pubmed/37873302
http://dx.doi.org/10.1101/2023.09.29.560234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592845/
https://www.ncbi.nlm.nih.gov/pubmed/37873302
http://dx.doi.org/10.1101/2023.09.29.560234

Ejemplares similares