Lysosomal proteomics reveals mechanisms of neuronal apoE4associated lysosomal dysfunction

ApoE4 is the primary risk factor for Alzheimer’s Disease. While apoE is primarily expressed by astrocytes, AD pathology including endosomal abnormalities and mitochondrial dysfunction first occurs in neurons. Lysosomes are poised at the convergence point between these features. We find that apoE4-ex...

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Detalles Bibliográficos
Autores principales: Krogsaeter, Einar K., McKetney, Justin, Marquez, Angelica, Cakir, Zeynep, Stevenson, Erica, Jang, Gwendolyn M., Rao, Antara, Zhou, Anton, Huang, Yadong, Krogan, Nevan J., Swaney, Danielle L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592882/
https://www.ncbi.nlm.nih.gov/pubmed/37873080
http://dx.doi.org/10.1101/2023.10.02.560519

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592882/
https://www.ncbi.nlm.nih.gov/pubmed/37873080
http://dx.doi.org/10.1101/2023.10.02.560519

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