Distinct features of ribonucleotides within genomic DNA in Aicardi-Goutières syndrome (AGS)-ortholog mutants of Saccharomyces cerevisiae

Ribonucleoside monophosphates (rNMPs) are abundantly found within genomic DNA of cells. The embedded rNMPs alter DNA properties and impact genome stability. Mutations in ribonuclease (RNase) H2, a key enzyme for rNMP removal, are associated with the Aicardi-Goutières syndrome (AGS), a severe neurolo...

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Detalles Bibliográficos
Autores principales: Kundnani, Deepali L., Yang, Taehwan, Gombolay, Alli L., Mukherjee, Kuntal, Newnam, Gary, Meers, Chance, Mehta, Zeel H., Mouawad, Celine, Storici, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592897/
https://www.ncbi.nlm.nih.gov/pubmed/37873120
http://dx.doi.org/10.1101/2023.10.02.560505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592897/
https://www.ncbi.nlm.nih.gov/pubmed/37873120
http://dx.doi.org/10.1101/2023.10.02.560505

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