Single-cell signaling analysis reveals that Major Vault Protein facilitates RasG12C inhibitor resistance

Recently developed covalent inhibitors for RasG12C provide the first pharmacological tools to target mutant Ras-driven cancers. However, the rapid development of resistance to current clinical Ras G12C inhibitors is common. Presumably, a subpopulation of RasG12C-expressing cells adapt their signalin...

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Detalles Bibliográficos
Autores principales: Zhang, Jason Z., Ong, Shao-En, Baker, David, Maly, Dustin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592919/
https://www.ncbi.nlm.nih.gov/pubmed/37873412
http://dx.doi.org/10.1101/2023.10.02.560617

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592919/
https://www.ncbi.nlm.nih.gov/pubmed/37873412
http://dx.doi.org/10.1101/2023.10.02.560617

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