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Post-ischemic inactivation of HIF prolyl hydroxylases in endothelium promotes maladaptive kidney repair by inducing glycolysis

Ischemic acute kidney injury (AKI) is common in hospitalized patients and increases the risk for chronic kidney disease (CKD). Impaired endothelial cell (EC) functions are thought to contribute in AKI to CKD transition, but the underlying mechanisms remain unclear. Here, we identify a critical role...

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Detalles Bibliográficos
Autores principales: Tiwari, Ratnakar, Sharma, Rajni, Rajendran, Ganeshkumar, Borkowski, Gabriella S., An, Si Young, Schonfeld, Michael, O’Sullivan, James, Schipma, Matthew J., Zhou, Yalu, Courbon, Guillaume, David, Valentin, Quaggin, Susan E., Thorp, Edward, Chandel, Navdeep S., Kapitsinou, Pinelopi P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592920/
https://www.ncbi.nlm.nih.gov/pubmed/37873349
http://dx.doi.org/10.1101/2023.10.03.560700