Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway

The endoplasmic reticulum (ER) stores large amounts of calcium (Ca(2+)), and the controlled release of ER Ca(2+) regulates a myriad of cellular functions. Although altered ER Ca(2+) homeostasis is known to induce ER stress, the mechanisms by which ER Ca(2+) imbalance activate ER stress pathways are...

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Detalles Bibliográficos
Autores principales: Pathak, Trayambak, Benson, J. Cory, Johnson, Martin T., Xin, Ping, Abdelnaby, Ahmed Emam, Walter, Vonn, Koltun, Walter A., Yochum, Gregory S., Hempel, Nadine, Trebak, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592933/
https://www.ncbi.nlm.nih.gov/pubmed/37873177
http://dx.doi.org/10.1101/2023.10.02.560521

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