Type I IFN signaling in the absence of IRGM1 promotes M. tuberculosis replication in immune cells by suppressing T cell responses

Polymorphisms in the IRGM gene are associated with susceptibility to tuberculosis in humans. A murine ortholog of Irgm, Irgm1, is also essential for controlling Mycobacterium tuberculosis (Mtb) infection in mice. Multiple processes have been associated with IRGM1 activity that could impact the host...

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Detalles Bibliográficos
Autores principales: Naik, Sumanta K., McNehlan, Michael E., Mreyoud, Yassin, Kinsella, Rachel L., Smirnov, Asya, Chowdhury, Chanchal Sur, McKee, Samuel R., Dubey, Neha, Woodson, Reilly, Kreamalmeyer, Darren, Stallings, Christina L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592944/
https://www.ncbi.nlm.nih.gov/pubmed/37873329
http://dx.doi.org/10.1101/2023.10.03.560720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592944/
https://www.ncbi.nlm.nih.gov/pubmed/37873329
http://dx.doi.org/10.1101/2023.10.03.560720

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