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Systemic pharmacological suppression of neural activity reverses learning impairment in a mouse model of Fragile X syndrome

The enhancement of associative synaptic plasticity often results in impaired rather than enhanced learning. Previously, we proposed that such learning impairments may result from saturation of the plasticity mechanism making it unavailable to be recruited at the appropriate synapses to support learn...

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Detalles Bibliográficos
Autores principales: Shakhawat, Amin Md, Foltz, Jacqueline G, Nance, Adam B., Bhateja, Jaydev, Raymond, Jennifer L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10592955/
https://www.ncbi.nlm.nih.gov/pubmed/37873217
http://dx.doi.org/10.1101/2023.10.05.561013